Zomacton (Somatropin) 5mg, Lyophilized (5mL vial)

Rh-GH, or Somatropin, is a pure form of recombinant growth hormone produced by either mammalian cells or Escherichia coli. The pituitary gland is where endogenous human growth hormone (hGH) is produced. The anabolic and growth-promoting actions of somatropin are indirectly mediated by somatomedins or insulin-like growth factors (IGFs). IGFs circulate around the body and attach to certain IGF receptors. IGF-1 and IGF-2 are the two known IGFs. Growth hormone appears to be primarily mediated by IGF-1, whereas IGF-2 has more insulin-like activity. The primary anabolic actions of IGFs include inducing cell proliferation and growth, stimulating amino acid transport, and stimulating DNA, RNA, and protein synthesis. IGF-1 is directly responsible of chondrogenesis, skeletal development, and soft tissue growth. By altering the cartilaginous growth regions of long bones, linear growth is encouraged. The quantity and size of skeletal muscle cells, the size of organs, and the activation of erythropoietin all contribute to the stimulation of growth. Growth hormone can affect the gut directly or indirectly through the systemic or local production of IGF. Growth hormone has been found to improve the transmucosal transfer of nutrients, electrolytes, and water in in-vivo experiments. Glucocorticoids prevent these indirect effects.