Sex Hormone Binding Globulin (SHBG) LabCorp

Sex Hormone Binding Globulin (SHBG) levels are under the positive control of estrogens and thyroid hormones, while they are suppressed by androgens. These influences dynamically control the liver synthesis of this carrier protein. Decreased levels of SHBG are frequently seen in hirsutism, virilization, obese postmenopausal women, and in women with diffuse hair loss. Increased levels may be present in cases of hyperthyroidism, testicular feminization, cirrhosis, male hypogonadism, pregnancy, women using oral contraceptives, and prepubertal children.