IGF-BP3 (Insulin-like Growth Factor-binding Protein 3) LabCorp

Insulin-like Growth Factor-binding Protein 3 (IGF-BP3) is the most abundant IGFBP speciesism in circulation and binds to 75%-90% of circulating IGF-1 in termary complex consisting of IGFBP-3, IGF-1 and acid-labile subunit (ALS). IGFBP-3 modulates the activity of IGF--1 and to increase their half lives. It has been postulated that IGFBP-3 is regulated by GH and originates in the liver as low levels were observed in patients with impaired hepatic function.